Platform Technology

Platform Technology

Innovative “Micro Needle Array “Technology enabled 3D Tissue Fabrication with 100% Cell.
Our Micro Needle Array technology was developed by focusing on cell’s nature to form aggregate. Conventional bioprinting must use scaffold such as Gel. On the other hand, our process enable tissue fabrication without gel, 100% cell only.
Each Needle is only 170um diameter and made with stainless steel. Regenova, Bioprinter, will fabricate 3D Tissue on Micro Needle Array. This process already successfully fabricated blood vessel, Beating Heart Tissue, implantable graft. This technology is also capable of making small tissue piece for in Vitro research which mimic in Vivo.

Sphere-like cell aggregates are secured in place by skewers.

The aggregates are allowed to fuse on the skewers for a few days.

The skewers are removed and the tissue is allowed to further mature.

3D Bioprinting process

STEP1

Spheroid (Cell Aggregate) Preparation

Culture enough cells and form Spheroids by aggregating tens of thousands of cells.

STEP2

Stacking / Printing

Stack spheroids onto needle as programmed 3D Data.

STEP3

Maturation

Spheroids shall fuse together and become one structure in a few days

STEP4

De-Cannulation

Remove Needle Array, and conduct further maturation for cells self-organization and relocation.

STEP5

3D Tissue Structure

3D tissue structure manufactured with 100% Cell is easy to meet safety standard and also shows long term.