株式会社サイフューズ

Organ

Osteochondral, cartilage

Osteochondral regeneration using constructs of mesenchymal stem cells made by bio three-dimensional printing in mini-pigs.

Yamasaki A, Kunitomi Y, Murata D, Sunaga T, Kuramoto T, Sogawa T, Misumi K. J Orthop Res. 2019 Jun; 37 (6): 1398-1408.

A preliminary study of osteochondral regeneration using a scaffold-free three-dimensional construct of porcine adipose tissue-derived mesenchymal stem cells.

Murata D, Tokunaga S, Tamura T, Kawaguchi H, Miyoshi N, Fujiki M, Nakayama K, Misumi K. J Orthop Surg Res. 2015 Mar 18;10:35.

Simultaneous regeneration of full-thickness cartilage and subchondral bone defects in vivo using a three-dimensional scaffold-free autologous construct derived from high-density bone marrow-derived mesenchymal stem cells.

Ishihara K, Nakayama K, Akieda S, Matsuda S, Iwamoto Y. J Orthop Surg Res. 2014 Oct 14; 9: 98.

Development of an immunodeficient pig model allowing long-term accommodation of artificial human vascular tubes.

Itoh M, Mukae Y, Kitsuka T, Arai K, Nakamura A, Uchihashi K, Toda S, Matsubayashi K, Oyama JI, Node K, Kami D, Gojo S, Morita S, Nishida T, Nakayama K, Kobayashi E. Nat Commun. 2019 May 21;10(1):2244. doi: 10.1038/s41467-019-10107-1.

iPSC-Derived Vascular Cell Spheroids as Building Blocks for Scaffold-Free Biofabrication.

Moldovan L, Barnard A, Gil CH, Lin Y, Grant MB, Yoder MC, Prasain N, Moldovan NI. Biotechnol J. 2017 Dec; 12 (12). Epub 2017 Nov 14.

Scaffold-Free Tubular Tissues Created by a Bio-3D Printer Undergo Remodeling and Endothelialization when Implanted in Rat Aortae.

Itoh M, Nakayama K, Noguchi R, Kamohara K, Furukawa K, Uchihashi K, Toda S, Oyama J, Node K, Morita S. PLoS One. 2015 Sep 1; 10 (9): e0136681.

Peripheral nerve regeneration following scaffold-free conduit transplant of autologous dermal fibroblasts: a non-randomised safety and feasibility trial

Ikeguchi R, Aoyama T, Noguchi T, Ushimaru M, Amino Y, Nakakura A, Matsuyama N, Yoshida S, Nagai-Tanima M, Matsui K, Arai Y, Torii Y, Miyazaki Y, Akieda S, Matsuda S. Commun Med . 2024 ;4:1-7. doi: 10.1038/s43856 024 00438 6.

Nerve regeneration using a Bio 3D conduit derived from umbilical cord–Derived mesenchymal stem cells in a rat sciatic nerve defect model

Iwai T, Ikeguchi R, Aoyama T, Noguchi T, Yoshimoto K, Sakamoto D, Fujita K, Miyazaki Y, Akieda S, Nagamura Inoue T, Nagamura F, Nakayama K, Matsuda S. PLoS One. 2024 ;19(12):e0310711. doi: 10.1371/journal.pone.0310711.

Nerve regeneration using the Bio 3D nerve conduit fabricated with spheroids

Ikeguchi R, Aoyama T, Tanaka M, Noguchi T, Ando M, Yoshimoto K, Sakamoto D, Iwai T, Miyazaki Y, Akieda S, Ikeya M, Nakayama K & Matsuda S. J Artif Organs. 2022 Dec; 25:289–297. Epub 2022 Aug 15. doi: 10.1007/s10047 022 01358 9.

A scaffold-free Bio 3D nerve conduit for repair of a 10-mm peripheral nerve defect in the rats.

Takeuchi H, Ikeguchi R, Aoyama T, Oda H, Yurie H, Mitsuzawa S, Tanaka M, Ohta S, Akieda S, Miyazaki Y, Nakayama K, Matsuda S. 2019 Nov 14. doi: 10.1002/micr.30533.

The Efficacy of a Scaffold-free Bio 3D Conduit Developed from Autologous Dermal Fibroblasts on Peripheral Nerve Regeneration in a Canine Ulnar Nerve Injury Model: A Preclinical Proof-of-Concept Study.

Mitsuzawa S, Ikeguchi R, Aoyama T, Takeuchi H, Yurie H, Oda H, Ohta S, Ushimaru M, Ito T, Tanaka M, Kunitomi Y, Tsuji M, Akieda S, Nakayama K, Matsuda S. Cell Transplant. 2019 Jun 12: 963689719855346.

The efficacy of a scaffold-free Bio 3D conduit developed from human fibroblasts on peripheral nerve regeneration in a rat sciatic nerve model.

Yurie H, Ikeguchi R, Aoyama T, Kaizawa Y, Tajino J, Ito A, Ohta S, Oda H, Takeuchi H, Akieda S, Tsuji M, Nakayama K, Matsuda S. PLoS One. 2017 Feb 13; 12 (2): e0171448.

In vivo and ex vivo methods of growing a liver bud through tissue connection.

Yanagi Y, Nakayama K, Taguchi T, Enosawa S, Tamura T, Yoshimaru K, Matsuura T, Hayashida M, Kohashi K, Oda Y, Yamaza T, Kobayashi E. Sci Rep. 2017 Oct 26; 7(1): 14085.

Scaffold-free 3D bio-printed human liver tissue stably maintains metabolic functions useful for drug discovery.

Kizawa H, Nagao E, Shimamura M, Zhang G, Torii H. Biochem Biophys Rep. 2017 Apr 14;10: 186-191.

Biofabricated Structures Reconstruct Functional Urinary Bladders in Radiation-Injured Rat Bladders.

Imamura T, Shimamura M, Ogawa T, Minagawa T, Nagai T, Silwal Gautam S, Ishizuka O. Tissue Eng Part A. 2018 Nov; 24 (21-22): 1574-1587.

Regeneration of diaphragm with bio-3D cellular patch.

Zhang XY, Yanagi Y, Sheng Z, Nagata K, Nakayama K, Taguchi T. Biomaterials. 2018 Jun; 167: 1-14.

Regeneration of esophagus using a scaffold-free biomimetic structure created with bio-three-dimensional printing.

Takeoka Y, Matsumoto K, Taniguchi D, Tsuchiya T, Machino R, Moriyama M, Oyama S, Tetsuo T, Taura Y, Takagi K, Yoshida T, Elgalad A, Matsuo N, Kunizaki M, Tobinaga S, Nonaka T, Hidaka S, Yamasaki N, Nakayama K, Nagayasu T. PLoS One. 2019 Mar 8; 14 (3): e0211339.

Replacement of Rat Tracheas by Layered, Trachea-Like, Scaffold-Free Structures of Human Cells Using a Bio-3D Printing System.

Machino R, Matsumoto K, Taniguchi D, Tsuchiya T, Takeoka Y, Taura Y, Moriyama M, Tetsuo T, Oyama S, Takagi K, Miyazaki T, Hatachi G, Doi R, Shimoyama K, Matsuo N, Yamasaki N, Nakayama K, Nagayasu T. Adv Healthc Mater. 2019 Apr;8(7):e1800983. doi: 10.1002/adhm.201800983. Epub 2019 Jan 11.

Scaffold-free trachea regeneration by tissue engineering with bio-3D printing.

Taniguchi D, Matsumoto K, Tsuchiya T, Machino R, Takeoka Y, Elgalad A, Gunge K, Takagi K, Taura Y, Hatachi G, Matsuo N, Yamasaki N, Nakayama K, Nagayasu T. Interact Cardiovasc Thorac Surg. 2018 May 1; 26 (5): 745-752.

Fabrication of scaffold-free tubular cardiac constructs using a Bio-3D printer.

Arai K, Murata D, Verissimo AR, Mukae Y, Itoh M, Nakamura A, Morita S, Nakayama K. PLoS One. 2018 Dec 17; 13 (12): e0209162.

Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting.

Ong CS, Fukunishi T, Nashed A, Blazeski A, Zhang H, Hardy S, DiSilvestre D, Vricella L, Conte J, Tung L, Tomaselli G, Hibino N. J Vis Exp. 2017 Jul 2;(125). doi: 10.3791/55438.

Biomaterial-Free Three-Dimensional Bioprinting of Cardiac Tissue using Human Induced Pluripotent Stem Cell Derived Cardiomyocytes.

Ong CS, Fukunishi T, Zhang H, Huang CY, Nashed A, Blazeski A, DiSilvestre D, Vricella L, Conte J, Tung L, Tomaselli GF, Hibino N. Sci Rep. 2017 Jul 4; 7 (1): 4566.

Modelling glioma invasion using 3D bioprinting and scaffold-free 3D culture.

van Pel DM, Harada K, Song D, Naus CC, Sin WC. J Cell Commun Signal. 2018 Dec; 12 (4): 723-730.

Review

Three-Dimensional Multilayered Microstructure Using Needle Array Bioprinting System

Shudo Y, MacArthur JW, Kunitomi Y, Joubert L, Kawamura M, Ono J, Thakore A, Jaatinen K, Eskandari A, Hironaka C, Shin HS, Woo Y PJ. Tissue Eng Part A. 2020 Mar;26(5 6):350–357. doi: 10.1089/ten.TEA.2019.0313.

Generation of biohybrid implants using a multipotent human periodontal ligament cell line and bioactive core materials

Ono T, Tomokiyo A, Ipposhi K, Yamashita K, Alhasan MA, Miyazaki Y, Kunitomi Y, Tsuchiya A, Ishikawa K, Maeda H. J Cell Physiol. 2021 Sep;236(9):6742–6753. Epub 2021 Feb 19. doi: 10.1002/jcp.30336.

Osteochondral regeneration using scaffold-free constructs of adipose tissue-derived mesenchymal stem cells made by a bio three-dimensional printer with a needle-array in rabbits

Murata D, Kunitomi Y, Harada K, Tokunaga S, Takao S, Nakayama K. Regen Ther. 2020 Dec;15:77–89. Epub 2020 Jul 24. doi: 10.1016/j.reth.2020.05.004.

Progress in scaffold-free bioprinting for cardiovascular medicine.

Moldovan NI. J Cell Mol Med. 2018 Jun; 22 (6): 2964-2969. Review.

Comparison of biomaterial-dependent and independent bioprinting methods for cardiovascular medicine.

Leni Moldovan, Clifford M. Babbeya, Michael P. Murphya, and Nicanor I. Moldovanc, Current Opinion in Biomedical Engineering 2017, 2: 124–131.

Principles of the Kenzan Method for Robotic Cell Spheroid-Based Three-Dimensional Bioprinting.

Moldovan NI, Hibino N, Nakayama K. Tissue Eng Part B Rev. 2017 Jun; 23 (3): 237-244.

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