1 Bone and cartilage regeneration

Articular cartilage has poor self-regeneration ability because it has no blood stream, and once it is injured, the injury often progresses to become more severe.
The previous cartilage regeneration technology covered only the thin cartilage layer of the articular surface and could not sufficiently treat cases with damage involving the subchondral bone layer that supports the cartilage layer.
In contrast to previous approaches, such as surgical therapies and symptomatic therapies, as well as artificial joint and cartilage cell implantation, Cyfuse has developed a steric bone and cartilage structure consisting of the mesenchymal stem cells derived from the patient's own adipose tissue and is advancing development of a new therapeutic option of implantation of this bone and cartilage structure into the site of bone and cartilage loss.
The previous research and development confirmed that the cells in the cell structure consisting of these cells only differentiate into cartilage and bone to regenerate the respective tissues after being implanted at the site of loss in patients.
Currently, Cyfuse is participating in the grants-in-aid for scientific research project of the National Institute of Health Sciences and Technology (AMED), and Cyfuse are undertaking the clinical development of this product under the support of participating in this project.
Thus, as patients who have the subchondral bone degenerated because of the advanced cartilage defect, such as arthropathy, will improve their quality of life (QOL) after regeneration of the joint to recover not only the cartilage but also subchondral bone if possible, simultaneous bone and cartilage regeneration is greatly expected.
From now on, Cyfuse are aiming to further advance the development of this cellular bone and cartilage, successfully regenerate normal articular cartilage that has been considered difficult before, and rescue a number of patients by the world's first breakthrough treatment method of simultaneous bone and cartilage regeneration.

Patients in need of bone and cartilage simultaneous regeneration